Associate Scientist, Automation

About Stylus Medicine: Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond. About the Role: Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team and build automation capabilities that accelerate the development of our next-generation gene editing tools. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. This individual will play a key role in discovery and engineering efforts, advancing recombinase-based genome editing platforms and collaborating across diverse R&D teams. Key Responsibilities & Accountabilities: - Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows - Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT) - Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products - Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens - Coordinate DNA synthesis and reagent orders with external vendors - Manage raw material, plasmid, and RNA inventories - Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks - Present findings clearly to other teams and contribute to scientific discussions and decision-making Qualifications & Skills: - BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field - Experience with automated liquid handling systems (e.g., Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting - Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus - Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR - Hands-on molecular biology experience, including cloning and RNA production and purification - Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling - Experience with laboratory inventory management - Track record of generating precise, reproducible data and performing rigorous quantitative analysis - Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences - Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects - Strategic thinker who effectively plans and prioritizes to maximize scientific impact - Collaborative mindset with a team-first attitude - Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty Pay Range: $105,000 - $120,000